Manipulating POMC to Optimize Your Testosterone

As discussed in the last article, Overview of POMC and downstream effects and regulation, proopiomelanocortin (POMC) is an important precursor peptide that plays a crucial role in various physiological processes, including the regulation of stress responses, appetite, and energy homeostasis. Given its broad range of effects, understanding how to manipulate POMC can help to optimize testosterone levels.

The Link Between POMC and Testosterone

POMC-derived peptides, particularly Adrenocorticotropic Hormone (ACTH), have a direct influence on cortisol production. While cortisol is essential for stress response and metabolism regulation, its chronic elevation can suppress testosterone synthesis. Therefore, managing POMC activity can indirectly influence testosterone levels by modulating cortisol production.